West Seram Regency is a regency of Maluku, Indonesia. It is mainly located on Seram, but includes various islands lying to the west of Seram - the largest being Manipa, Kelang and Buano, as well as the smaller islets of Babi, Pua, Masowoi, and Marsegu.
It covers a land area of 5,014.24 km2, and had a population of 164,654 at the 2010 Census and 212,393 at the 2020 Census; the official estimate as at mid 2025 was 218,637 (comprising 109,683 males and 108,954 females). The principal town lies at Piru, a port at the northern coast of Latira Bay (Teluk Latira) which is a northwards extension of Piru Bay (Teluk Piru) and almost separates the Huamual Peninsula from the rest of Seram Island.